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What can you buy over the counter for restless leg syndrome? Your doctor will prescribe the best treatment plan for you. Dopamine agonists: These are most often the first medicines used to treat RLS. These drugs, including pramipexole (Mirapex), rotigotine (Neupro), and ropinirole (Requip), act like the neurotransmitter dopamine in the brain. Can Benadryl help RLS? Finally, many common drugs can aggravate RLS symptoms, including caffeine, alcohol, and nicotine; the antihistamine drug diphenhydramine (Benadryl), which is found in many over-the-counter cold, allergy, and sleeping pills; prescription antidepressants such as amitriptyline (Elavil), fluoxetine (Prozac), and Can gabapentin make RLS worse? However, they may cause a worsening of symptoms for some people after daily use. Anticonvulsants: These agents, such as gabapentin (Neurontin) and gabapentin enacarbil (Horizant), may help relieve the symptoms of RLS as well as any chronic pain or nerve pain.
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