What are the symptoms of high estrogen levels? Symptoms of high estrogen in women bloating. swelling and tenderness in your breasts. fibrocystic lumps in your breasts. decreased sex drive. irregular menstrual periods. increased symptoms of premenstrual syndrome (PMS) mood swings. headaches. How long does an estrogen shot last? These medications are usually injected by a health care professional once every 3 to 4 weeks. When the estradiol valerate form of estrogen injection is used to treat the symptoms of prostate cancer, it is usually injected by a health care professional once every 1 to 2 weeks. Is weight gain a side effect of estradiol? Many women notice that they gain weight during this time in their life. One reason why people might gain weight around menopause is changing hormone levels. One form of estrogen called estradiol decreases at menopause. Lower levels of estradiol may lead to weight gain.
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